Conization can be considered a definitive treatment as hysterectomy does not improve the outcome [IV, C].

Execute all communication requests from external partners in accordance with ESTRO's support policy. Focus Groups are high-turnover agile teams active across all the areas covered by ESTRO. Are you interested in contributing to the advancement of European RT by becoming more engaged in ESTRO? Do you wish to expand your network by working with leading experts from all over Europe and beyond? The aim of the diagnostic work-up is to determine the extent of the locoregional and/or metastatic disease [V, B].

The expertly crafted formula enables optimised breakdown and detoxification of estrogen. This gives your body the best chance to lose stubborn lower body fat, regulate hormonal balance and potentially help with the appearance of cellulite. Ingredients Radical surgical approaches such as radical hysterectomy, trachelectomy or parametrectomy represent overtreatment and should not be performed for patients with T1a1 disease [IV, D].

Follow-up should be performed/coordinated by a physician experienced with follow-up care after radiotherapy and BT including monitoring of early, and late treatment-related side effects [V, A].Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Dyba T, Randi G, Bray F et al (2021) The european cancer burden in 2020: incidence and mortality estimates for 40 countries and 25 major cancers. Eur J Cancer 157:308–47 Surgical LN staging is recommended in patients with T1b1 tumor with clear margins and absence of residual tumor on imaging (including non-suspicious LN). In case of histological evidence of PLN involvement, definitive CTRT is recommended and PALND, at least up to inferior mesenteric artery, may be considered for staging purposes [III, B]. In patients with pelvic sidewall involvement, extended pelvic surgery can be considered in specialized centers. Surgery must aim for a complete tumor resection (R=0) also with the help of special techniqu es (LEER, out of box procedures), if required [IV, B].