Phenytoin doubles caffeine clearance, although caffeine does not affect the metabolism of phenytoin.

Box 1. Caffeine content of commonly consumed items compared with paracetamol with caffeine tablets 13 Beverage/item Acetylsalicylic acid is contraindicated in children under the age of 12 because of the risk of Reye syndrome, except in Kawasaki disease, when used with intravenous immunoglobulin.However, the concentrations of regulatory cytokines (IL-4 and IL-10) will not decrease; TGF-beta is a possible target for acetylsalicylic acid. Talk to a doctor at once if you take too much of this medicine, even if you feel well. Do not take anything else containing paracetamol while taking this medicine. Duyff RL. Think your drinks. In: Academy of Nutrition and Dietetics Complete Food and Nutrition Guide. 5th ed. Houghton Mifflin Harcourt; 2017.

Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help to protect the environment. 6. FURTHER INFORMATIONWhat is in this medicine: If you take blood thinning medicines (anticoagulants e.g. warfarin) and you need to take a pain reliever on a daily basis, talk to your doctor because of the risk of bleeding. But you can still take occasional doses of Parasolve® Extra Effervescent Tablets at the same time as anticoagulants Taking your medicine with food and drinkAcetaminophen, or paracetamol, is the most commonly used analgesic and antipyretic drug worldwide.The drug may be used without a prescription and is the drug of choice in patients who cannot have treatment with non-steroidal anti-inflammatory drugs(NSAIDs) as well as those patients with bronchial asthma, peptic ulcer disease, hemophilia, salicylate-sensitized people, children under 12 years of age, and pregnant or breastfeeding women. PATIENT INFORMATION LEAFLET Parasolve® Extra 500 mg/65 mg Effervescent Tablets (paracetamol and caffeine)

Care is advised in the administration of paracetamol to patients with renal or hepatic impairment. The hazard of overdose is greater in those with non- cirrhotic alcoholic liver disease.a) Is on long term treatment with carbamazepine, phenobarbitone, phenytoin, primidone, rifampicin, St John's Wort or other drugs that induce liver enzymes.