The immunomodulatory activities of Dendronan ® in vivo in relation to cell mediated and humoral immunity was investigated using a long-term immunosuppressed mice model. A253 cells were pre-treated with DP for 12hr before TNF-α addition, then NF-κB, phosphorylation of MAPKs, ROS generation, mitochondrial membrane potential and proapoptotic proteins were examined. Indeed, the cell proliferation is the most important characteristic of the tumor cells and could be indicated by the cell viability. Attenuation of 6-OHDA toxicity cells via mitochondria protection and NF-κB modulation Inhibition of the neurotoxicity of 1-methyl-4-phenyl pyridinium (MPP +). The in vitro study showed that HPS-1B23 possessed an enhancing effect on TNF-α production and the peak of 1130.

w., an effective T/C value of 172% with a significant increase in life span compared to control was obtained. Therapeutic roles of polysaccharides from Dendrobium Officinale on colitis and its underlying mechanisms. investigated antitumor activities of denbinobin and the mechanism involved in Jurkat leukemic cells [ 46]. The antitumor activity has been investigated in estrogen receptor (ER) positive breast cancer by treating T47D cells with erianin and its effects have been evaluated on multiple cancer-associated pathways [ 41]. Saliva and salivary glands biopsies from labial glands of patients were collected and examined by immunoreactivity and immunohistochemistry techniques.explored the amelioration of ethanol extract of Dendrobium chrysotoxum on streptozotocin (STZ)-induced DR and its engaged mechanisms.

Recently, a bibenzyl-dihydrophenanthrene derivative, named dendrosignatol, together with 3,4-dihydroxy-3,4-dimeth-oxybibenzyl, dendrocandin B, dendrocandin I and dendrofalconerol A, isolated from the whole plant od Dendrobium signatum, showed appreciable cytotoxic activity against three human cancer cell lines, including breast cancer MDA-23 1, liver hepatocellular carcinoma HepG2 and colorectal tumor HT-29 cells [ 51]. Beneficial Effects of Macroporous Resin Extract of Dendrobium candidum Leaves in Rats with Hyperuricemia Induced by a High-Purine Diet. Also, DF-A was shown to suppress EMT, as indicated by cadherin switch from N- to E-cadherin and decrease of Snail, Slug and vimentin, revealing thus the potential of DF-A as an anti-metastatic agent [ 44]. When taken by mouth: There isn't enough information to know if dendrobium is safe or what the side effects might be when taken by mouth. Ischemic brain injury and neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases, are a problem of growing importance in an aging population.Polysaccharides from Dendrobium officinale exerted the strongest immunomodulatory activities on mouse macrophage line RAW 264.

Pregnancy and Breast-feeding: There isn't enough information to know if dendrobium is safe to take during pregnancy or breast-feeding. Chrysotobibenzyl, erianin and chrysotoxine had a certain degree of inhibition ratios against BChE (30. DHP-W2 mainly consisted of glucose, xylose, galactose and trace of galacturonic acid, and its average molecular weight was approximately 73 kDa.Moreover, VEGF- and bFGF-induced cell proliferation, migration and tube formation of HUVECs was markedly inhibited by moscatilin. w. on diabetic mice for 7 days, while DCP was orally administered at the concentration of 50-200 mg/kg b. The majority of reported studies deal with in vitro evaluations of potential anticancer effects of crude Dendrobium extracts or isolated compounds.

Moreover, aging can be examined from an immunological point of view, because it is generally accepted, that the immune system does not work as well as we grow older and becomes altered with age. Indeed, a large number of pharmacological activities were assigned to different Dendrobium species, such as anti-inflammatory [ 5], anti-platelet aggregation [ 6], hepatoprotective [ 7], anti-fibrotic [ 8], anti-viral [ 9], anti-fungal [ 10], antimicrobial [ 11], antioxidant [ 12- 14], anti-diabetic [ 15], neuroprotective [ 16], immunomodulatory and anticancer [ 17]. DTP-N represents the major portion of DTP, which might explain why the Mw of DTP and DTP-N were similar to each other, with an average Mw of 305 kDa and 221 kDa, respectively. Concerning Dendrobium isolates, the inhibitory mechanism of erianin has been investigated on retinal neoangiogenesis and its contribution to the amelioration of DR.Interestingly, only a high dose of erianin (80 and 160 nM) could inhibit the proliferation of T47D cells. DP was found to consist of mannose, glucose, galactose, arabinose, xylose and glucuronic acid in the molar ratio of 10:0. The prescriptions are mostly preventive or assisting diabetes treatments, reducing blood glucose, improving yin-deficiency, and accompanying patients with chemotherapy or radiotherapy.