ColdZyme Mouth & Throat Spray (Not Nasal Spray) - Cold Virus Treatment & Symptom Relief - Use at First Signs of a Cold - Menthol Flavour 20ml

Product Information

Muik A, et al. Neutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA vaccine-elicited human sera. Science. 2022;375:678–80. https://doi.org/10.1126/science.abn7591. Common symptoms include arunny or stuffy nose and sore throat. Symptoms may also include amild cough and headache with fever. Anordinary cold usually lasts for fewer than ten days and, onaverage, people have two to five colds peryear. 3 Boots. ColdZyme ® OneCold Mouth Spray Against Common Cold. Available online: https://www.boots.com/wcsstore/cmsassets/Boots/Content/Products/Cold%20-%20CAT:%20A00000545/10183984.P/CZ_OneCold_leaflet_20140624_english.pdf (accessed on 20 March 2021).

There is no way to completely eliminate the danger of entering a confined space with other passengers, but along with getting your vaccination and any boosters you're eligible for, there are a couple of other rules of thumb to follow which could further bring you peace of mind while heading on holiday. CZ-MD inactivated rhinovirus 1A: 91.7% (1.08 log10); rhinovirus 42: 92.8% (1.14 log10); hIV virus H3N2: 96.9% (1.51 log10); RSV: 99.9% (2.94 log10); adenovirus T2: 64.5% (0.45 log10); human coronavirus [ 38]. Furthermore, no cytotoxicity was detected for ColdZyme at any dilution tested. The study was conducted by the US company Microbac Laboratories Inc an independent, accredited and certified laboratory," the company stated in an official release. In first experiments, we monitored primary normal human bronchial epithelial (NHBE) cell infection using BA.1 as well as the recent VOCs BA.4/5 in absence and presence of the ColdZyme® mouth spray. For infection assays, a multiplicity of infection (MOI) of 0.01 was used to determine morphogenesis and cytopathic effects of SARS-CoV-2 infection in human airway epithelial cells.

Author Contributions

Shirogane, Y.; Takeda, M.; Iwasaki, M.; Ishiguro, N.; Takeuchi, H.; Nakatsu, Y.; Tahara, M.; Kikuta, H.; Yanagi, Y. Efficient multiplication of human metapneumovirus in Vero cells expressing the transmembrane serine protease TMPRSS2. J. Virol. 2008, 82, 8942–8946. [ Google Scholar] [ CrossRef][ Green Version] Press down on the pump and spray 2 puffs (1 dose) every two hours up to 6 times daily while you are exposed to the cold virus. National Institute of Health, U.S. National Library of Medicine. Evaluation of ColdZyme ® on Experimentally Induced Common Cold. (COLDPREVII). Available online: https://clinicaltrials.gov/ct2/show/NCT02479750 (accessed on 20 March 2021). Björkman, E.V.; Edebo, A.; Oltean, M.; Casselbrant, A. Esophageal barrier function and tight junction expression in healthy subjects and patients with gastroesophageal reflux disease: Functionality of esophageal mucosa exposed to bile salt and trypsin in vitro. Scand. J. Gastroenterol. 2013, 48, 1118–1126. [ Google Scholar] [ CrossRef] Robertson, S. Novel Mutation Identified in SARS-CoV-2 Spike Protein from Sweden. Available online: https://www.news-medical.net/news/20200804/Novel-mutation-identified-in-SARS-CoV-2-spike-protein-from-Sweden.aspx (accessed on 20 March 2021).

There was no evidence of efficacy of trypsin and there were no planned or ongoing clinical trials identified in trials databases (ClinicalTrials.gov or EUDAMED). The % participants that were CC-free (so not developing CC and protected during the study period against respiratory virus) varied between 9–39% among Viruprotect ® users, lower than in non-users (30.5–63%). Early on in the pandemic, the Department for Transport suggested that airlines should offer a reduced food and drink service, and limit the sale of non-essential items. Cision. Enzymatica AB: Court Ruling Put Restrictions on Marketing of Enzymatica’s Cold Spray in Germany. Available online: https://news.cision.com/enzymatica-ab/r/enzymatica-ab--court-ruling-put-restrictions-on-marketing-of-enzymatica-s-cold-spray-in-germany,c2752043 (accessed on 20 March 2021). Davison, G.; Perkins, E.; Jones, A.W.; Swart, G.M.; Jenkins, A.R.; Robinson, H.; Dargan, K. ColdZyme ® mouth spray reduces duration of upper respiratory tract infection symptoms in endurance athletes under free living conditions. Eur. J. Sport Sci. 2020. [ Google Scholar] [ CrossRef] [ PubMed]In a smaller open-label study in athletes, the proportions of virus-protected persons per treatment group were not released, but there was no significant difference in number of CC episodes/person between the CZ-MD and control group [ 53]. The study mixing (unweighted) data obtained from winter seasons over 2 years claimed a reduction of 3.5 days with CZ-MD versus the controls. However, patients in the control group felt less need for using OTC medication than in the CZ-MD group (38 versus 48%, not significant), undercutting the relevance of the findings. Moreover, the reduction in training load during CC, the return to normal training and the total number of training days were not significantly different between the groups. Kido, H. Influenza virus pathogenicity regulated by host cellular proteases, cytokines and metabolites, and its therapeutic options. Proc. Jpn. Acad. Ser. B. Phys. Biol. Sci. 2015, 91, 351–368. [ Google Scholar] [ CrossRef][ Green Version] National Institute of Health, U.S. National Library of Medicine. Evaluation of the Sue of Various Assessments of Common Cold Symptoms for Proof of Efficacy of Coldzyme Mouth Spray. Available online: https://clinicaltrials.gov/ct2/show/NCT03831763 (accessed on 20 March 2021). Professor Sally Bloomfield from the London School of Tropical Medicine and Hygiene recommends switching on the overhead fan so you are breathing air directly from these filters rather than that of the people seated around you.