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A: No, absolutey not. Because chelation is a sodium chloride solution and Plaquex can only be mixed with dextrose 5 % or glucose 5% and NOTHING ELSE !!! Chelation and Plaquex infusions can be done one after the other on the same day, they just can't be mixed in the same infusion bag. Chelation removes select cations from tissues by forming a chelator‐chelate complex subsequently excreted by the kidneys or liver.
Both TACT and PATCH study found no significant difference in quality of life scores between chelation and placebo groups. An open‐label pilot study conducted in 10 patients with moderate‐to‐severe PAD (n=10; diabetes prevalence, 100%) found a significant improvement in the 36‐Item Short Form Health Survey scores, including gains of 30 and 35 points, from a baseline of 45, in the physical and mental score medians, respectively.The Plaquex® Therapy Formula has a long history of practical use, spanning over 70 years in about one-fourth of the world’s countries. It has been featured in over 126 clinical studies involving over 8,300 patients in the past 38 years. EDTA treatment showed significant improvement in both ABI and walking distance. Placebo subgroup was switched to EDTA treatment following 10 infusions to significant improvement seen in treatment subgroup. After initial 10 infusions, treatment group walking distance improved by 2.65 times baseline distance, compared to 1.1 times baseline distance in placebo group. ABI at rest improved by 0.23 after 10 infusions, compared to 0.01 in placebo group. After final infusion, walking distance in original treatment group was three times the baseline distance, compared to two times the baseline distance in placebo group. ABI at rest improved on average by 0.29 for treatment group after final infusion, compared to 0.24 in placebo group (No SD provided) Given the prolonged timespan during which the extracted studies were conducted, numerous EDTA infusion regimens were used. Each infusion regimen used different minerals, EDTA salt, and EDTA dosage, resulting in a potential source of confounding for comparison between studies. Most studies (n=17) reported using Na 2EDTA as the chelating agent, with only one study using calcium Na 2EDTA. Similarly, dosage varied across studies, as some reported using a fixed EDTA dose for all patients, whereas others adjusted chelating agent dose based on body weight or glomerular filtration rate. No clear pattern emerged between EDTA dosage and patient improvement. Choice of minerals and amount of water present in the infusion may also have had a confounding effect. In studies examining renal function, a high amount of saline in the solution may have helped improve dehydrated patients, rather than EDTA chelation. Two studies that reported improved renal function did not indicate the solution components, but the improvement may have been related to the volume of crystalloid infused. The process is known as emulsification, where large lipids are broken down into smaller ones. In doing so, Plaquex Infusion helps reduce plaque buildup within arterial walls and restore proper blood flow. Ehrly, A.M. Report no. 842276 of March 17, 1975 – and R. Blendin in: Phosphatidylcholine, H. Peeters (ed.) Springer: Berlin 1976, 228-236 Blagosklonov, A.S. et al. Kardiologiya 26 (1986) 35-38 3 Nei’mark Al, Zhukov, VN et al. Use of isradipine and EPL for protection of the kidney during extracorporal lithotripsy Urologiia I Nefrologiia. (6):19-21, 1998 Nov-Dec 4 Kuntz, E.
Overall, 17 suggested improved outcomes, † 5 reported no statistically significant effect of EDTA treatment, Similarly, cadmium has also been associated with reduced glutathione activity, cadmium‐induced cell death through apoptotic pathway activation, and DNA methylation, resulting in increased oxidative stress, inflammation, and endothelial cell death. A: Adults up to 100 lbs: 40 cc, Adults heavier than 100 lbs: 50 cc . Asian patients usually can't be dosed higher than 25-30 cc, as they tend to react with extreme fatigue. In these patients it's best to divide one vial of 50 cc into two treatments. EDTA was also found to reduce serum cholesterol levels and levels remained lower after end of treatment There is only one compounding pharmacy in the USA that is licensed to compound Plaquex®: AnazaoHealth in Las Vegas NV. There is only one compounding pharmacy in Canada licensed to compound Plaquex®: Smith’s Pharmacy in Toronto.An important factor in the development of athersclerosis is lipid peroxidation. A close relationship was found between lipid peroxidation and increased platelet aggregation. In vivo and in vitro studies show a decrease in lipid peroxidation parameters when PC is applied. It's surmised that increased Glutathione and SOD levels help reduce/prevent lipid peroxidation. Increased accumulation of cholesterol in RBC membranes impair the fluidity and functioning of the membrane and RBC deformability, making it hard for RBCs to pass through tight capillaries. An improved passage of red blood cells through microfilters and the normalisation of RBC aggregation was found in patients given 500mg by IV injection and taking 1.8 g orally/day for three months. Studies confirmed that an increase in LCAT activity lowered the cholesterol content in the membranes of red blood cells, thereby making the membranes more fluid and deformable. 28,40,50,51,52 There are medical clinics in the US, Canada, Cyprus, Thailand, Indonesia, Malaysia, India, The Philippines, Mexico, Nigeria and South Africa, UAE doing Plaquex® therapy. The TACT trial was the first large randomized controlled trial to investigate the effect of chelation therapy on cardiovascular events in patients with a history of MI. The trial results suggest that chelation therapy may reduce the risk of some cardiovascular events. The Importance of Plaquex Maintenance Therapy
Three studies analyzed urinary metal levels at baseline and posttreatment for lead. In 2 studies, lead was measured pretreatment and during follow‐up. Both studies indicated significant decreases in urinary lead from baseline to last point of follow‐up, with mean decreases of 8.40μg/L (SD, 4.29μg/L) (74.40% decrease) Plaquex® isn’t just a Phosphatidylcholine. It’s one of the very few products on the world market that contains exactly the kind of DLPC needed to get the job(s) done. It contains pure 100% DLPC, 1,2 dilinoleoylphosphatidylcholine of a certain percentage. Other formulations contain PC with saturated fatty acid chains from egg or mixed chains; some also contain other forms of PC such as phosphatidylethanolamine. Some contain a much lower percentage of PC that in turn can cause severe health problems. Plaquex® contains the most effective and desirable form of phosphatidylcholine, and all studies were done with this form of DLPC since the 1950s. Saba, P., F. Galeone, F. Savadorini, E. Pagliai, G. Guidi, A. Scalabrigo: Effects of soybean polyunsaturated phosphatdiylcholine on hyperlipoproteinemia. Curr. Therap. Res. 24 (1978) 299-306 The Plaquex® Formula has a long history of use, spanning over 70 years and in about one-fourth of the world’s countries. Developed initially to dissolve fatty embolisms during and after trauma surgery, it has since been found to have many applications, including treating liver and kidney disease. Fasoli,A.: Clinical evaluation of polyenephosphatidylcholine (PPC) – effects on the serum lipid and lipoprotein patterns. Therap. Select. Risk/Benefit Assess. Hypolipid. Drugs (G. Ricci, R. Paoletti, Pocciari, Poggiolini, Eds. ) Raven Press, New York (1982) 257-262Two studies measured brachial artery diameter after chelation treatment and found no significant difference in diameter between baseline and follow‐up (Table 5). EDTA is a synthetic amino acid and polydentate chelator with high affinity for divalent cations, such as lead, cadmium, and calcium. All of these hypotheses, however, must be taken cautiously, as they have not been demonstrated in patients. patients with angina pectoris, 31 patients with intermittent claudication, and 25 patients with some form of cerebrovascular disease A number of studies were done with EKG diagnostics. Depending on the PC dosage and the duration of treatment, an improvement of EKG findings could be achieved in many cases. Among them they found a dose-related disappearance of S-T depressions and reversal of previously negative T-waves to positive. These favourable changes went along with symptomatic relief of sternocardiac symptoms. Exercise tolerance as tested on the bicycle ergometer improved. The phase until S-T depression occurred became longer, with the depressions themselves being less distinct.
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