Molecular Biology of the Cell

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The original idea of a book such as MBoC belonged exclusively to James Watson. In the early 1970s, he wisely spotted a latent hurdle for his long-time vision of transforming the whole biology field into a molecular science. He recognized that the knowledge of cell biology at the time was almost entirely based on light and electron microscopy investigations, and for students this hardly integrated any new molecular biology. Therefore, Watson believed in the need for a new textbook that would combine these two fields. As Martin Raff recalls, for Watson producing MBoC would be a “very important way of modernising the way cell biology was taught and perhaps even how cell biology was done.” Molecular Biology of the Cell: Reference Edition is conceptual, accurate and authoritative. An extensive, detailed index provides instant access to the most crucial information and concepts, while a glossary with more than 1,300 entries has been designed for rapid access to technical vocabulary. By skillfully extracting the fundamental concepts from this enormous and ever-growing field, the authors provide the coherent framework needed to effectively access the primary literature.

Hedgehog Proteins Act Through a Receptor Complex of Patched and Smoothened, Which Oppose Each Other The RecA Protein and its Homologs Enable a DNA Single Strand to Pair with a Homologous Region of DNA Double Helix Interactions of the Oocyte With Its Surroundings Define the Axes of the Embryo: the Role of the Egg-Polarity Genes A comparison of the cell cycles of fission yeasts and budding yeasts. (A) The fission yeast has a typical eucaryotic cell cycle with G 1, S, G 2, and M phases. In contrast with what happens in higher eucaryotic cells, however, the nuclear envelope of the (more...) To perform its function, each transport vesicle that buds from a compartment must be selective. It must take up only the appropriate proteins and must fuse only with the appropriate target membrane. A vesicle carrying cargo from the Golgi apparatus to the plasma membrane, for example, must exclude proteins that are to stay in the Golgi apparatus, and it must fuse only with the plasma membrane and not with any other organelle.When Activated by Antigen, a B Cell Switches From Making a Membrane-Bound Antibody to Making a Secreted Form of the Same Antibody

Combinations of Start-Transfer and Stop-Transfer Signals Determine the Topology of Multipass Transmembrane Proteins

A Large Drop in Redox Potential Across Each of the Three Respiratory Enzyme Complexes Provides the Energy for H + Pumping Some Key Regulatory Genes Define a Cell Type; Others Can Activate the Program for Creation of an Entire Organ A Special Nucleotide-Polymerizing Enzyme Synthesizes Short RNA Primer Molecules on the Lagging Strand In a Reaction Center, Light Energy Captured by Chlorophyll Creates a Strong Electron Donor from a Weak One

By Providing an Inexhaustible Source of Reducing Power, Photosynthetic Bacteria Overcame a Major Evolutionary Obstacle Epithelial Cells Have Two Distinct Early Endosomal Compartments But a Common Late Endosomal Compartment

Many Proteins and Lipids Seem to Be Carried Automatically from the Golgi Apparatus to the Cell Surface