A.Vogel Ivy-Thyme Complex Drops | Food Supplement | Fresh Tinctures of Ivy & Thyme | Liquorice Root | Suitable for Vegans | 50ml

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Borugă O, et al. (2014). Thymus vulgaris essential oil: chemical composition and antimicrobial activity. Jukic, M., Politeo, O., Maksimovic, M., Milos, M., and Milos, M. In vitro acetylcholinesterase inhibitory properties of thymol, carvacrol and their derivatives thymoquinone and thymohydroquinone. Phytother.Res 2007;21(3):259-261. View abstract. Gulyas, A., Repges, R., & Dethlefsen, U. (1997). Therapy of chronic obstructive pulmonary diseases in children. Atemwegs- Lungenkr, 23(5), 291–294.

Kraft, K. (2004). Tolerability of dry extracts from ivy ( Hedera helix) leaves for children. Zeitschrift fur Phytotherapie, 25(4), 179–181.Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Walker, Paul (2 September 2021). "What Is a Bouquet Garni? Easy Homemade Bouquet Garni Recipe, Plus Tips for Cooking With Bouquet Garni - 2022 - MasterClass". Masterclass . Retrieved 23 March 2022.

Sakkas H, Papadopoulou C. Antimicrobial activity of Basil, Oregano and Thyme essential oils. J Microbiol Biotechnol. 2016 Dec 20. doi: 10.4014/jmb.1608.08024. [Epub ahead of print] Review. View abstract. Grande S, Bogani P, de Saizieu A, et al. Vasomodulating potential of mediterranean wild plant extracts. J Agric Food Chem 2004;52:5021-6. . View abstract.All studies reviewed concluded that ivy leaf extract is effective for the treatment of URTIs. After 7 to 10 days of treatment, symptoms like cough or expectoration are improved or cured in a large majority of patients. It has to be noted that only one placebo-controlled RCT could be retrieved. This trial showed superior results as to symptom relief and speed of recovery in the intervention group treated with a combination drug of ivy and thyme extract [ 22]. Chesty coughs are normal accompaniments of illnesses like the common cold or influenza. They might occur as soon as symptoms present themselves and persist well beyond when a patient no longer has either virus in their system. Meister A, Bernhardt G, Christoffel V, Buschauer A. Antispasmodic activity of Thymus vulgaris extract on the isolated guinea-pig trachea: discrimination between drug and ethanol effects. Planta Med 1999;65:512-6. . View abstract. EA 575 (Prospan®) syrup, drops, effervescent tablets, or lozenges H. helix 105 mg DE/5 mL, DER 5-7.5:1, E30% HEK293 cells expressing a biosensor with cAMP binding domain fused to a luciferase were used to determine intracellular cAMP concentrations. Upon cAMP binding, a conformational change of the fusion protein is induced, leading to luciferase activation and oxidation of the substrate luciferin to oxyluciferin. This reaction emits chemiluminescent light which correlates with the cAMP concentration. Cells pre-treated with the ivy preparation showed a significant and dose-dependent increased cAMP level under adenylyl cyclase and β 2AR stimulating conditions as found for α-hederin as a positive control ( Figure3). A similar effect was also observed on HASM cells for α-hederin [ 8]. Remarkably, the ivy/thyme combination mediated only a tendentially weak increase in cAMP level, although a significant increase in β 2AR binding was observed in our FCS experiments. To clarify this surprising finding, the cAMP level of cells was examined after pre-treatment with a thyme preparation. Interestingly, the cAMP level was not affected by the thyme preparation compared to control. In contrast an elevated cAMP level was found in human COPD airway epithelial cells pre-treated with a thyme extract under non-stimulating conditions [ 19]. Although the effect was comparable to isoprenaline, the authors did not comment on a possible mode of action. Comparing the cAMP levels, the thyme fluid extract in the ivy/thyme combination may affect the signaling of isoprenaline-activated β 2AR and thus their functionality.