SkinCeuticals Phloretin CF Serum

Product Information

But I love fragrance-free products. Fragrance is one of the most (if not the most) irritating ingredient in skincare products. By taking it out, you greatly lower the risk someone will have an allergic reaction to it. What you can see straight away is the brightening effect. Phloretin CF makes my skin glow! It also makes it a little softer and smoother. How Does Skinceuticals Phloretin CF Compare To Skinceuticals CE Ferulic?

Do not store it in the fridge after it has been opened. Do not store in the sun as it will destabilise the ingredients. Provides advanced environmental protection from skin-damaging free radicals caused by sun and pollution SkinCeuticals Phloretin CF Antioxidant Vitamin C Discoloration Serumis a patented triple antioxidant formulation that visibly improves the appearance of discoloration, fine lines and uneven skin tone. This potent vitamin C serum features a synergistic combination of 2% phloretin, 10% pure vitamin C (l-ascorbic acid), and 0.5% ferulic acid. These antioxidants provide powerful antioxidant protection against atmospheric skin aging – environmental damage and premature signs of aging caused by free radicals from UVA/UVB, infrared radiation (IRA), and ozone pollution (O3). Evidence is now emerging in support of the PI3K/Akt pathway of NF-κB activation which is targeted by phloretin. Readers should bear in mind that this pathway is far too complex and in some cases, inhibition of the pathway displays protective effects while in others, it worsens the inflammation (see review, [ 121]). More research is thus needed to ascertain the significance of either enhancing or suppressing the PI3K/Akt pathway by phloretin.

That’s why we recommend considering Formulyst Active Serum, a multi-tasking serum that contains a blend of antioxidant vitamins C and E, ferulic acid, niacinamide, and panthenol to help shield your skin from environmental assaults that age your skin. It’s the ultimate antioxidant formulation to help your skin look brighter, healthier, and more youthful. Ferulic Acid: A plant-based antixoidant, ferulic acid neutralizes free radicals and enhances the antixoidant benefits of phloretin and vitamins C and E. What are the Best Skin Care Products of 2023? What are the key ingredients in SkinCeuticals Phloretin CF? According to a 2008 study, it gives similar results to the classic combo of Vitamin C + Vitamin E + Ferulic Acid:

One of the main benefits of ascorbic acid is its potent antioxidant activity. Ascorbic acid donates electrons to neutralize free radicals from environmental factors such as UVA/UVB radiation, infrared radiation (IRA), and ozone pollution (O3). This is important because the harmful effects of free radicals occur as direct chemical alterations of the cellular DNA, the cell membrane, and cellular proteins, including collagen. Damaged collagen manifests as signs of premature skin aging, including wrinkles, lines, and sagging skin. By protecting collagen and other skin components, ascorbic acid helps to prevent signs of aging. This is one way that SkinCeuticals Phloretin CF provides advanced environmental protection. The next key ingredient in SkinCeuticals Phloretin CF is phloretin, a flavonoid derived from apples and the root bark of fruit trees including apple, pear, and grapefruit. Phloretin is an antioxidant that neutralizes damaging free radicals. It also helps increase cell turnover, improves the appearance of discoloration, and helps other beneficial ingredients penetrate deeper into the skin. Reduces NO, ROS, TNF-α, and IL-6 production; downregulates the expression of E. coli-induced COX-2, NF-κB pathway, and HO-1 in a concentration-dependent manner. Suppresses the production of ROS and proinflammatory cytokines; inhibits MAPKs (ERK, JNK, and p38 MAPK), and NF-κB.The serum is fragrance-free. I know some people don’t like fragrance-free products because they don’t smell like a fragrant bouquet of roses or like a salty ocean breeze. If that’s you, this may be a deal-breaker for you. In a diabetic neuropathy study induced by STZ, phloretin (50 or 25 mg/kg, i.p.) or in combination with duloxetine (15 mg/kg duloxetine and 25 mg/kg phloretin, i.p.) was shown to ameliorate the thermally induced hyperalgesia, sciatic nerve oxidative stress markers (tissue MDA, NO, SOD activity and GSH levels); and sciatic nerve TNF-α and IL-6 levels [ 107]. This, together with the normalization of histopathological and structural changes, suggests the potential of phloretin as a neuroprotective agent. In HFD- and STZ-induced diabetes models in mice, phlorizin (10–20 mg/kg, p.o.) was shown to alleviate depression symptoms, reversed the decline in GSH, BDNF, and its receptor (TrkB), cyclic AMP-responsive element-binding protein (CREB) and ERK level [ 108]. Inflammatory markers were not, however, assessed in this study. Always put the serum in the fridge for 12 hours before you first use it to restabilise the ingredients. Do not shake the bottle before use.

An animated representation of a skin cell appears and then oxidants move into the cell and it begins to shrivel. Text, Healthy skin cell. Skin cell with oxidative stress. Three-Time Allure Best of Beauty Award Winner: Best Breakthrough, Best Serum, Best Antioxidant Anti-Ager. Elle, Shape, Vogue, InStyle, New Beauty, People.

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KEY INGREDIENTS & BENEFITS: Alpha Tocopherol (neutralizes free radicals and replenishes skin lipids), Ferulic Acid (neutralizes free radicals and enhances the antioxidant benefits of vitamins C and E) This study confirms the protective role of a unique mixture of antioxidants containing vitamin C, ferulic acid, and phloretin on human skin from the harmful effects of UV irradiation. Phloretin, in addition to being a potent antioxidant, may stabilize and increase the skin availability of topically applied vitamin C and ferulic acid. We propose that antioxidant mixture will complement and synergize with sunscreens in providing photoprotection for human skin.” Ferulic acid: a plant-based antioxidant, ferulic acid neutralizes free radicals and enhances the antioxidant benefits of phloretin and vitamins C and E. In the morning, after cleanser and before sunscreen to boost its sun protection. You could potentially use it in the evening as well, but I prefer to alternate my actives and use Vitamin C in the morning and retinol or an exfoliant at night.

Pure vitamin C (l-ascorbic acid): lauded for its superior antioxidant benefits, this highly potent form of pure vitamin C neutralizes damaging free radicals and protects against oxidative stress while providing visible anti-aging benefits. In the various sections of this review ( Section 2, Section 3, Section 4, Section 5, Section 6, Section 7, Section 8, Section 9, Section 10 and Section 11), the anti-inflammatory potential of phloretin that has been established through studies both in vitro and in vivo are outlined. Indeed, phloretin does also possess various other pharmacological effects including anticancer properties. Readers should bear in mind that carcinogenesis and the process of cancer metastasis including angiogenesis share some aspects of inflammation biology. Hence, the reported anti-inflammatory mechanism of phloretin could also be relevant to its anticancer properties. The focus of this section is however to summarise the anti-inflammatory mechanism of phloretin that accounts for its diverse other effects in vitro and in vivo. Phloretin: Derived from apples and the root bark of fruit trees including apple, pear, and grapefruit, this antioxidant neutralizes damaging free radicals, helps improve cell turnover, and improves the appearance of discoloration Experienced retinol users generally tolerate a higher concentration. Once your skin is comfortable with Retinol 0.3, you may step up to Retinol 0.5. This concentration can also be used by first-timers with resistant skin that rarely experiences irritation. For particularlyoily, acne-prone skin, I recommend you use products that contain AHAs (Glycolic Acid) and Azelaic Acid,' says DrUkeleghe. These make for a great addition to you pregnancy skincare routine, because they're also great for treating pigmentation. The Mask of PregnancyIn the human lung epithelial cells (A549 cell line), the effect of phloretin as an anti-inflammatory agent is similar to those described for macrophages ( Section 2). Huang et al. [ 79] have shown that phloretin (3–100 μM) treatment of A549 cells could alleviate inflammatory conditions induced by IL-1β as evidenced by a reduction in the expression of COX-2, and production of PGE 2, IL-8, MCP-1, and IL-6. In addition to relieving these potent inflammatory markers of lung inflammation, ICAM-1 gene, and protein expression as well as monocyte adhesion to inflammatory A549 cells were suppressed. This data suggests that phloretin acts as an anti-inflammatory agent by targeting both leucocytes and direct effect on lung epithelial cells. As a mechanism of action, the study [ 79] also revealed that protein kinase B (Akt) and MAPK phosphorylation as well as NF-κB subunit p65 protein translocation into the nucleus were suppressed by phloretin. Once again, this effect was shown to be limited to phloretin but not phlorizin. As indicated in the preceding section ( Section 2), Songyang et al. [ 35] have shown the potential of phloretin in suppressing acute lung injury via inhibition of the GLUT1-induced glycolysis in macrophages. Phloretin was also reported to suppress GLUT1-dependent glycolysis which is associated with age-dependent fibrogenesis of the lung [ 80]. In an asthmatic mice model of airway inflammation induced by ovalbumin, phloretin administration (5, 10, or 20 mg/kg, i.p.) reduced goblet cell hyperplasia, eosinophil infiltration (also neutrophil, lymphocyte, and macrophages), and the severity of airway hyperresponsiveness [ 81]. In addition to suppressing the oxidative stress level (reduction in MDA and increase in glutathione (GSH) levels) in the lung and reduced production of cytokines (IL-4, TNF-α, IL-6, IL-5, and IL-13), chemokines (CCL11 and CCL24) and adhesion molecules (ICAM-1) expression in the lung. The mRNA expression of many inflammatory mediators (CCL11, CCL24, ICAM-1, IL-4 IL-5, IL-13, IFN-γ, MUC5AC, Gob5 (goblet-cell derived protein chloride channel regulator, calcium-activated-1), COX-2, and iNOS) were also suppressed. In the same study [ 81] in vitro using TNF-α and IL-4-activated human lung epithelial cell line (BEAS-2B cells), phloretin (10 and 30 µM) was shown to suppress the production of chemokines (CCL11, CCL24, and CCL26) as well as epithelial cells adhesion to monocytes (THM-1 cells). Given the compound also inhibited ROS production in BEAS-2B cells, a dual effect on both lung oxidative stress and inflammation was evident for the compound. As a mechanism of action, an increased level of expression of Nrf2 in lung cells was also induced by phloretin. These data overall support that already discussed ( Section 2) for phloretin-mediated protection of the lung from LPS-induced injury in vivo [ 55].