Bee Health Propolis Lozenges 114 g Pack of 2

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Fuliang HU, Hepburn HR, Xuan H, et al. Effects of propolis on blood glucose, blood lipid and free radicals in rats with diabetes mellitus. Pharmacol Res. 2005;51(2):147-152. doi:10.1016/j.phrs.2004.06.011 Propolis allergy often cross-reacts with Myroxylon pereirae ( balsam of Peru) as there are 13 known constituents in common. Other recognised cross-reactions due to shared ingredients (commonly cinnamic acid, cinnamyl alcohol, vanillin) include: Mahmoud, A. S., Almas, K., and Dahlan, A. A. The effect of propolis on dentinal hypersensitivity and level of satisfaction among patients from a university hospital Riyadh, Saudi Arabia. Indian J Dent.Res 1999;10(4):130-137. View abstract. The effect of ethanolic extract of propolis against experimental diabetes mellitus-associated changes was examined. Diabetes was induced experimentally in rats by i.p. injection of streptozotocin (STZ) in a dose of 60mg/kg bwt for 3 successive days. Blood urea nitrogen (BNU), creatinine, glucose, lipid profile, malondialdehyde (MDA), and urinary albumin were measured. Superoxide dismutase (SOD), glutathione (GSH), catalase (CAT), and MDA were measured in the renal tissue. The results showed decreased body weight and increased kidney weight in diabetic animals. Compared to the control normal rats, diabetic rats had higher blood glucose, BNU, creatinine, total cholesterol, triglycerides, low-density lipoprotein-cholesterol (LDL-C), MDA and urinary albumin, and lower high-density lipoprotein-cholesterol (HDL-C) levels. Moreover, renal tissue MDA was markedly increased while SOD, GSH, and CAT were significantly decreased. Oral administration of propolis extract in doses of 100, 200, and 300mg/kgbwt improved the body and kidney weights, serum glucose, lipid profile, MDA, and renal function tests. Renal GSH, SOD, and CAT were significantly increased while MDA was markedly reduced. These results may suggest a strong antioxidant effect of propolis which can ameliorate oxidative stress and delay the occurrence of diabetic nephropathy in diabetes mellitus [ 74].

Beekeepers – propolis allergy can develop after many years of exposure. In one study the average exposure time before developing propolis allergy was 9.5 years (range 0.1-35 years). Davoodi SH, Yousefinejad V, Ghaderi B, et al. Oral propolis, nutritional status and quality of life with chemotherapy for breast cancer: a randomized, double-blind clinical trial. Nutr Cancer 2022;74(6):2029-2037. View abstract.Honey and propolis provide beneficial effect on human health. Since ancient times propolis has been extensively employed by man, especially in folk medicine to treat several maladies. Egyptians used bee glue to embalm their cadavers as they well knew about its putrefactive properties. Incas employed propolis as an antipyretic agent. Greek and Roman physicians used it as mouth disinfectant and as an antiseptic and healing product in wound treatment, prescribed for topical therapy of cutaneous and mucosal wounds [ 2]. Propolis was listed as an official drug in the London pharmacopoeias of the 17th century. Due to its antibacterial activity, in Europe propolis became very popular between the 17th and 20th centuries. In Italy bee glue was used as a violin varnish [ 3] by Stradivari. In the end of the 19th century, propolis was widely used due to its healing properties and in the Second World War it was employed in several Soviet clinics for tuberculosis treatment, due to the observed decline of lung problems and appetite recovery. In the Balkan states propolis was applied to treat wounds and burns, sore throat, and stomach ulcer [ 4]. The first scientific work with propolis was published in 1908 including its chemical properties and composition which was further indexed to chemical abstract [ 5]. Antioxidants have been shown to be capable of scavenging free radicals and thereby protecting lipids and other compounds such as vitamin C from being oxidized or destroyed [ 58]. It is probable that active free radicals, together with other factors, are responsible for cellular aging and degradation in such conditions as cardiovascular diseases, arthritis, cancer, diabetes, Parkinson's disease, and Alzheimer's disease. Oxidative damage may also result in poor liver function. Studies on rats in vitro show that propolis extracts protect against damage to liver cells [ 59]. Nikbaf-Shandiz M, Tutunchi H, Khoshbaten M, Nazari Bonab H, Ebrahimi-Mameghani M. Propolis supplementation in obese patients with non-alcoholic fatty liver disease: effects on glucose homeostasis, lipid profile, liver function, anthropometric indices and meta-inflammation. Food Funct. 2022;13(22):11568-78. View abstract. Igarashi G, Segawa T, Akiyama N, et al. Efficacy of Brazilian propolis supplementation for japanese lactating women for atopic sensitization and nonspecific symptoms in their offspring: a randomized, double-blind, placebo-controlled trial. Evid Based Complement Alternat Med 2019;2019:8647205. View abstract.

Chan GCF, Cheung KW, Sze DMY. The immunomodulatory and anticancer properties of propolis. Clinic Rev Allerg Immunol. 2013;44(3):262-273. Schmidt, H., Hampel, C. M., Schmidt, G., and et al. [Double-blind trial of the effect of a propolis-containing mouthwash on inflamed and healthy gingiva]. Stomatol.DDR. 1980;30(7):491-497. View abstract. Propolis is a complex mixture made by bee-released and plant-derived compounds. In general, raw propolis is composed of around 50% resins, 30% waxes, 10% essential oils, 5% pollen, and 5% of various organic compounds [ 1, 8, 9]. More than 300 constituents were identified in different samples [ 7– 10] and new ones are still being recognized during chemical characterization of new types of propolis [ 2, 11, 12]. The proportions of the various substances present in the propolis depend upon its place and time of collection. Volpert, R. and Elstner, E. F. Interactions of different extracts of propolis with leukocytes and leukocytic enzymes. Arzneimittelforschung 1996;46(1):47-51. View abstract.

Propolis is a natural adhesive and resin-like substance produced and used by bees to construct and repair their hives. Honeybees produce propolis by collecting pollen, resin, and other substances from various plants such as poplar and coniferous trees and mixing it with beeswax and salivary enzymes they secrete. Propolis is a complex mixture of several chemicals and has been used as traditional medicine since ancient times to treat several ailments. Steinberg, D., Kaine, G., and Gedalia, I. Antibacterial effect of propolis and honey on oral bacteria. Am.J.Dent. 1996;9(6):236-239. View abstract. Samadi N, Mozaffari-Khosravi H, Rahmanian M, Askarishahi M. Effects of bee propolis supplementation on glycemic control, lipid profile and insulin resistance indices in patients with type 2 diabetes: a randomized, double-blind clinical trial. J Integr Med. 2017;15(2):124-134. View abstract. Kuo CC, Wang RH, Wang HH, Li CH. Meta-analysis of randomized controlled trials of the efficacy of propolis mouthwash in cancer therapy-induced oral mucositis. Support Care Cancer. 2018;26(12):4001-4009. View abstract.

Pasupuleti VR, Sammugam L, Ramesh N, Gan SH. Honey, propolis, and royal jelly: a comprehensive review of their biological actions and health benefits. Oxid Med Cell Longev. 2017;2017:1259510. doi:10.1155/2017/1259510 Jautová J, Zelenková H, Drotarová K, Nejdková A, Grünwaldová B, Hladiková M. Lip creams with propolis special extract GH 2002 0.5% versus aciclovir 5.0% for herpes labialis (vesicular stage): randomized, controlled double-blind study. Wien Med Wochenschr 2019;169(7-8):193-201. View abstract. Soleimani D, Miryan M, Hadi V, et al. Effect of propolis supplementation on athletic performance, body composition, inflammation, and oxidative stress following intense exercise: a triple-blind randomized clinical trial. Food Sci Nutr 2021;9(7):3631-40. View abstract. It offers an array of benefits for many ailments and is one of nature’s richest sources of bioflavonoids for immune support. Cai T, Anceschi U, Tamanini I, et al. Xyloglucan, hibiscus and propolis in the management of uncomplicated lower urinary tract infections: a systematic review and meta-analysis. Antibiotics (Basel) 2021;11(1):14. View abstract.

Ingredients

Santos VR, Gomes RT, de Mesquita RA, et al. Efficacy of Brazilian propolis gel for the management of denture stomatitis: a pilot study. Phytother Res. 2008;22(11):1544-7. View abstract. Sforcin, J. M., Fernandes, A., Jr., and et al. Seasonal effect on Brazilian propolis antibacterial activity. J Ethnopharmacol. 2000;73(1-2):243-249. View abstract. Bee Health guarantees the bioflavonoids present are naturally occurring flavonoids, with no synthetic substances added. This unique natural substance is subject to tests for potency and quality. Braakhuis A. Evidence on the health benefits of supplemental propolis. Nutrients. 2019;11(11):2705. doi: 10.3390/nu11112705 Amoros, M., Simoes, C. M., Girre, L., Sauvager, F., and Cormier, M. Synergistic effect of flavones and flavonols against herpes simplex virus type 1 in cell culture. Comparison with the antiviral activity of propolis. J Nat Prod. 1992;55(12):1732-1740. View abstract.