A313 Vitamin A Pommade (Closest Version to Avibon Available)

Product Information

The cream form, with its more fluid texture, is better suited to skin irritations with a larger surface area and is more easily absorbed by the skin. Synthetic vitamin A (concentrate) - oily form 200,000 IU per 100 g of ointment. Excipients: macrogol 400, macrogol 4000, polysorbate 80 Farooq, U., Mahmood, T., Shahzad, Y., Yousaf, A. M. & Akhtar, N. (2018). Comparative efficacy of two anti-aging products containing retinyl palmitate in healthy human volunteers. Journal of Cosmetic Dermatology. 2018 Jun; 17(3): 454-460. Alas, I didn’t make it there before the manufacturer, Sanofi, suddenly discontinued it in 2013. According to a trade publication at the time: “Sanofi has stopped marketing its Avibon vitamin A skin ointment in France. After batches of the ointment were recalled in March 2013 due to ‘product stability’ problems, Sanofi’s ‘various attempts at improvement’ had not resulted in ‘a product that met current quality standards.’” 2 Generally it is best applied at night, and sunscreen is recommended if A313 is on skin outdoors. If sensitivity occurs reduce use to once every 2-3 days or as recommended by a dermatologist. This overview is not a substitute for medical advice. 200,000 U.I. pure vitamin A concentrate. *Not suitable for pregnant or nursing women. Please consult your doctor. Buy now with confidence.

By penetrating deep beneath your epidermis (the outer layer of your skin) and neutralising free radicals, this potent little ingredient boosts your skin's production of elastin, collagen, and comedolytic agents. These natural chemicals work simultaneously with retinol's auxiliary exfoliating effect to uncover fresh layers of youthful-looking skin, essentially speeding up the skin's natural regeneration process and consequently thwarting any and every skin issue that springs to mind. In your twenties, starting a healthy skincare regimen when you're young will help you to age gracefully and keep your skin in the best shape possible," says Dr. Farber. "Women should start off using retinol creams during their twenties, as this is the time when sun damage starts to become apparent." How to Incorporate Retinol This minimalist, hypoallergenic, and non-comedogenic formula contains no preservatives, no fragrance, no parabens, no colourants, and no lanolin. Enriched with 0.3% retinol and an added retinol booster complex that improves efficacy even further, it helps to stimulate collagen and elastin to firm, smooth, and resurface the skin. What is retinyl palmitate? It’s not retinol—but it is another type of retinoid called a retinyl ester. Retinyl esters are the mildest vitamin A derivatives, because they need to be converted three times within the skin: first to retinol, then to retinaldehyde, and finally to retinoic acid (the active form of vitamin A). 3This stuff is definitely powerful with a 0.5 percent retinol formula, so it's perfect for those of you looking for a step up from your beginner formulas. But don't let its potency scare you: it uses entrapped retinol, which gradually releases over time for an exfoliation that won't burn. What makes this retinol cream really stand out is its other hero ingredients. It includes jojoba oil and shea butter for more firming action, plus vitamins C and E to neutralize free radicals. Talk about a multi-tasker! Watson, R. E. B., Long, S. P., Bowden, J. J., Bastrilles, J. Y., Barton, S. P. & Griffiths, C. E. M. (2008). Repair of photoaged dermal matrix by topical application of a cosmetic 'antiageing' product. The British Journal of Dermatology. 2008 Mar; 158(3): 472-7. A fat-soluble vitamin, vitamin A occurs in the human body in the form of retinol , retinal (in the retina), retinoic acid (in bones and mucous membranes) or retinyl palmitate (reserves stored in liver). Vitamin A was first isolated from the retina, hence the name " retinol" . Vitamin A is obtained directly by the body from foods of animal sources where it is present in the form of retinol. So why is it so mystifying? Some people say retinol is the best thing that ever happened to them; others complain that it leaves their skin red and dry. Then there's the question of how to incorporate it into your skincare routine—you can't just slather it on willy-nilly or you could get burned, maybe even literally. Plus, with the hundreds of products on the market, how do you know which formula is right for you?

Ointment A313 with vitamin A in a 50 g tube, on sale in our online pharmacy, is a vitamin A-based medicine indicated for the adjunctive treatment of irritative dermatitis . In addition, we have Macrogol, and this is the ingredient that has solved the mystery. Macrogol is an ingredient used in laxatives. Yes, you read that right. Laxatives! When used in a laxative formula, Macrogol draws water from the rest of the body, into your bowel to help loosen things up. Therefore, if you are applying this ingredient, topically to your skin, theoretically Macrogol could draw water to the surface of the skin to create a plump appearance. This would indeed explain the immediate plumping effects both myself, and my friend, experienced. To Conclude. Vitamin A is present in many medicines, some of which are available for self-medication : avoid combining them with this medicine because an overdose of vitamin A is likely to cause serious side effects. Take the dosage and duration of treatment prescribed by your doctor.

It’s less likely, but also possible, that A313 could cause acne if it doesn’t agree with your skin. For how to tell the difference between purging and breakouts, see this tutorial. How Do You Layer A313 with Other Products?

This 3-in-1 eye cream minimizes the appearance of under-eye lines, puffiness and dark circles while providing hydration, nourishment and a smoothing effect around the delicate eye contour. Pro tip: Soak two cotton pads in Thermal Spring Water; place them on your eyelids for 10 minutes for a wonderfully spa-like, refreshing sensation. Afterwards, gently apply this eye treatment with your ring finger. Consistent use will yield bright, firm, luminous and soft skin around the eyes. If you’re new to retinoids, it’s important to go slow at first—especially because it’s one of the strongest over-the-counter retinoids. I suggest the “1-2-3” rule: Some dermatologists believe that applying retinoids to damp skin increases the risk of irritation, since damp skin is more permeable and enhances absorption. But others say this is a myth, so it’s really up to you. If you want to be on the safe side, try waiting about 20 minutes after washing your face. 2. Use a Pea-Sized AmountSince it takes about four to six weeks to get through the retinoid adjustment period (also known as “retinization”), it’s normally recommended to start slowly.

I had a chat with Dr. Marine Vincent, founder of The French Pharmacy (a lovely brand which I will be talking about next week). Dr. Marine also found A313 equally confusing but did understand the ingredients list a little better than I. She suggested that it was in fact the additional ingredients (other than the vitamin A) that helped the skin absorb the vitamin A more effectively. She also claimed one specific ingredient, Macrogol, was an effective moisture magnet drawing water to the surface of the skin which would contribute to a plumping effect. It’s also a great ingredient for skin penetration. French women are famous for their flawless, foundation-free skin, and A313 may be the reason why. Just like its predecessor, Avibon, it’s a pharmaceutical-grade vitamin A cream that is sold over-the-counter in France. If you ask me, it’s one of the country’s best beauty secrets. So they kind of leave you on your own, but not to worry—I’ve got some tips: 1. Apply at Night to Clean, Dry Skin Tolleson, W. H., Cherng, S., Xia, Q., Boudreau, M., Yin, J. J., Wamer, W. G., Howard, P. C., Yu, H. & Fu, P. P. (2005). Photodecomposition and Phototoxicity of Natural Retinoids. International Journal of Environmental Research and Public Health. 2005 May; 2(1): 147–155. Pharma Développement does not make any specific claims about what A313 can treat. However, based on the current research about retinyl palmitate, here’s what you might expect:

Now, here’s where it gets a little confusing. In my correspondence with Pharma Développement, I was told that the “200,000 IU of vitamin A” is equivalent to 0.06% retinyl palmitate. However, according to National Institutes of Health (NIH), 1 IU of vitamin A is equivalent to 0.3 micrograms of retinol. 4 Zasada, M. & Budzisz, E. (2019). Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments. Advances in Dermatology and Allergology. 2019 Aug; 36(4): 392–397. Irritative dermatitis mainly affects areas that contain sebum, mainly the face, but also the scalp and torso My confusion increased. Vitamin A, any form, regardless of strength takes time to work. It will be a while before you start to notice the benefits. Therefore, why on earth was the A313 giving me amazing, immediate benefits based on such a low-strength vitamin A content? I will confess that I did not do that. I jumped right in with nightly applications, since I’d already been using Shani Darden Retinol Reform (reviewed here). Although that product has since been reformulated, its active ingredient at the time was a retinyl ester, so I figured A313 would be similar.