Synbiotic 7 Probiotic | Friendly Bacteria | High Strength | 40 Billion CFU Spanning 7 Scientifically Studied strains | Including Bacillus Subtilis | Vegan | Link Nutrition | No Refrigeration Needed

Product Information

Ritual ushers in the future of gut health with Gut Health Synbiotic+ — a 3-in-1 supplement that contains a complete trifecta of prebiotics, probiotics, and postbiotics to support a balanced gut microbiome. Horvath A, Leber B, Feldbacher N, Tripolt N, Rainer F, Blesl A, Trieb M, Marsche G, Sourij H, Stadlbauer V (2020) Effects of a multispecies synbiotic on glucose metabolism, lipid marker, gut microbiome composition, gut permeability, and quality of life in diabesity: a randomized, double-blind, placebo-controlled pilot study. Eur J Nutr 59:2969–2983 Two reviewers independently evaluated the eligibility of retrieved studies, and any discrepancies were submitted to the corresponding author for resolution. Titles and abstracts of all articles were initially screened, and then full texts were carefully assessed according to the inclusion and exclusion criteria. Pandey KR, Naik SR, Vakil BV (2015) Probiotics, prebiotics and synbiotics-a review. J Food Sci Technol 52:7577–7587

Ohshima T, Kojima Y, Seneviratne CJ, Maeda N (2016) Therapeutic application of synbiotics, a fusion of probiotics and prebiotics, and biogenics as a new concept for oral candida infections: a mini review. Front Microbiol 7:10 Ghorbani Z, et al. The effect of synbiotic as an adjuvant therapy to fluoxetine in moderate depression: A randomized multicenter trial. Arch Neurosci. 2018;5(2):e60507. Mofidi F, Poustchi H, Yari Z, Nourinayyer B, Merat S, Sharafkhah M, Malekzadeh R, Hekmatdoost A (2017) Synbiotic supplementation in lean patients with non-alcoholic fatty liver disease: a pilot, randomised, double-blind, placebo-controlled, clinical trial. Br J Nutr 117:662–668 Sergeev IN, Aljutaily T, Walton G, Huarte E (2020) Effects of symbiotic supplement on human gut microbiota, body composition and weight loss in obesity. Nutrients 12:222It is important to note that this product requires a monthly subscription as the company believes that probiotics and prebiotics, alongside a healthy diet, balanced nutrition, exercise, and lifestyle, are cornerstone tools to building foundational health. The prebiotic PreforPro® helps target undesirable gut bacteria and allows healthy probiotic bacteria to have more room to flourish and take advantage of helpful nutrients in both the small and large intestines. While the postbiotic Corbiome® Tributyrin fuels the cells that make up the gut lining, supports gut barrier function, and keeps the intestinal gut flora healthy.

Davani-Davari D, Negahdaripour M, Karimzadeh I, Seifan M, Mohkam M, Masoumi SJ, Berenjian A, Ghasemi Y (2019) Prebiotics: definition, types, sources, mechanisms, and clinical applications. Foods 8:92 Synbiotic+ prides itself in using two of the world’s most clinically studied probiotic strains — the BB-12® (Bifidobacterium anamalis ssp. lactis) and LGG® (Lactobacillus rhamnosus), which provide live microorganisms that contribute to a healthy gut microflora and relieve gastrointestinal discomforts such as mild bloating, gas, and diarrhea. These also help support immune health and offer additional protection against cavities. Sanders ME, et al. Probiotics and prebiotics in intestinal health and disease: from biology to the clinic. Nat Rev Gastroenterol Hepatol. 2019;16(10):605–16. Chunchai T, Thunapong W, Yasom S, Wanchai K, Eaimworawuthikul S, Metzler G, Lungkaphin A, Pongchaidecha A, Sirilun S, Chaiyasut C (2018) Decreased microglial activation through gut–brain axis by prebiotics, probiotics, or synbiotics effectively restored cognitive function in obeseinsulin resistant rats. J Neuroinflamm 15:11Amongst studies applying probiotics as the intervention, 4 studies used a single strain, and the remaining 7 studies used multiple strains. The depressive symptom scores were reduced significantly, regardless of whether single or multiple strains were applied (multiple: SMD = -0.27 [-0.43, -0.10], P = 0.002; single: SMD = -0.42[-0.62, -0.22], P< 0.001). Additionally, no significant heterogeneity between groups was observed ( P = 0.249), with significant heterogeneity within the subgroup of multiple strains ( I 2 = 53.6%, P = 0.014), and absent heterogeneity within the subset of single strain ( I 2 = 0.0%, P = 0.817) (Fig. 3d). Margolis KG, Cryan JF, Mayer EA. The microbiota-gut-brain axis: from motility to mood. Gastroenterology. 2021;160(5):1486–501. Asemi Z, Aarabi MH, Hajijafari M, Alizadeh SA, Razzaghi R, Mazoochi M, Esmaillzadeh A (2017) Effects of synbiotic food consumption on serum minerals, liver enzymes, and blood pressure in patients with type 2 diabetes: a double-blind randomized cross-over controlled clinical trial. Int J Prev Med 8:43

Guiné R de PF, Silva ACF. Probiotics, prebiotics and synbiotics. Funct Foods Sources, Heal Eff Futur Perspect. 2016;(May):143-207. doi:10.1201/b15561-2 Batista VL, da Silva TF, de Jesus LCL, Coelho-Rocha ND, Barroso FAL, Tavares LM, Azevedo V, Mancha-Agresti P, Drumond MM (2020) Probiotics, prebiotics, synbiotics, and paraprobiotics as a therapeutic alternative for intestinal mucositis. Front Microbiol 11:544490 Tajabadi-Ebrahimi M, Sharifi N, Farrokhian A, Raygan F, Karamali F, Razzaghi R, Taheri S, Asemi Z (2017) A randomized controlled clinical trial investigating the effect of synbiotic administration on markers of insulin metabolism and lipid profiles in overweight type 2 diabetic patients with coronary heart disease. Exp Clin Endocrinol Diabetes 125:21–27 Markowiak P, Śliżewska K (2017) Effects of probiotics, prebiotics, and synbiotics on human health. Nutrients 9:1021

EFSA (2017) Scientific opinion on the update of the list of QPS-recommended biological agents intentionally added to food or feed as notified to EFSA (2017 update). EFSA J 15:1–177 These statements have not been evaluated by the Food and Drug Administration. Probiotic supplements are not drugs and therefore are not intended to diagnose, treat, cure, or prevent any disease or health condition.

in-1 ACV Gut Health from Seedwell sets itself apart from the other products on this list by combining a prebiotic and probiotic supplement with the additional bacterial benefits of apple cider vinegar. Haro C, et al. Intestinal microbiota is influenced by gender and body mass index. PLoS One. 2016;11(5):e0154090. Accumulating studies have shown the effects of gut microbiota management tools in improving depression. We conducted a meta-analysis to evaluate the effects of prebiotics, probiotics, and synbiotics on patients with depression. We searched six databases up to July 2022. In total, 13 randomized controlled trials (RCTs) with 786 participants were included. The overall results demonstrated that patients who received prebiotics, probiotics or synbiotics had significantly improved symptoms of depression compared with those in the placebo group. However, subgroup analysis only confirmed the significant antidepressant effects of agents that contained probiotics. In addition, patients with mild or moderate depression could both benefit from the treatment. Studies with a lower proportion of females reported stronger effects for alleviating depressive symptoms. In conclusion, agents that manipulate gut microbiota might improve mild-to-moderate depression. It is necessary to further investigate the benefits of prebiotic, probiotic and synbiotic treatments relative to antidepressants and follow up with individuals over a longer time before these therapies are implemented in clinical practice.Its probiotic blend contains a synergistic formula of 13 powerful probiotic strains designed for digestive and immune health. It includes Bifidobacterium lactis HN019 , Lactobacillus rhamnosus L08R , Lactobacillus acidophilus, Lactobacillus gasseri L22G, and more. Romijn AR, et al. A double-blind, randomized, placebo-controlled trial of Lactobacillus helveticus and Bifidobacterium longum for the symptoms of depression. Aust N Z J Psychiatry. 2017;51(8):810–21. NS & MY contributed the basic theme of article (conceptualization) and also prepared the original draft-writing. Amit K & SK reviewed the therapeutic potential. Ashwani K & RS reviewed the mechanism of action. AKS was involved in reviewing the whole content and finalized the manuscript. Corresponding author Wall R, et al. Impact of administered bifidobacterium on murine host fatty acid composition. Lipids. 2010;45(5):429–36.