Solaray, Lithium Aspartate, 5 mg, 100 Capsules

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Clinical and epidemiological data point to specific properties of Li in prevention of suicidal behavior, which are at least partially independent of its mood-normalizing effect [ 65]. Li is a well-known element of normothymic action and has been used as a part of preventive treatment of patients with suicidal tendencies, as confirmed at the level of meta-analyses [ 56, 68, 76, 77, 78] and randomized placebo-controlled clinical trials [ 79, 80]. Some studies have demonstrated that bottled water from different manufactures can reach high concentrations of Li [ 67]. In one Slovakian product, a Li concentration reached as much as nearly 10,000 μg/L. The mean concentration of Li in European bottled waters, however, was estimated at 0.94 μg/L [ 67]. The mean Li content in tap water and bottled water in Scandinavia (Norway, Sweden, Finland, Iceland) accounted for 0.54 and 0.64 μg/L, respectively [ 69]. Długaszek and Połeć (2012) reported 2.1–14.9 mg/L of Li in spring and medicinal waters produced in Poland with the higher values observed for the latter [ 70]. In German, mineral waters were reported to contain 1.5–1320 μg/L of Li [ 71]; while in Romania, the highest concentration was as low as 0.0719 μg/L [ 72]. These differences in Li concentrations are likely caused by different ambient Li contents in various geographical regions. Ohgami H, Terao T, Shiotsuki I, Ishii N, Iwata N (2009) Lithium levels in drinking water and risk of suicide. Br J Psychiatry 194:464–465 Kavanagh L, Keohane J, Cleary J, Cabellos GG, Lloyd A (2017) Lithium in the natural waters of the south east of Ireland. Int J Environ Res Public Health 14:561 Many people with anxiety, depression, and other mood impairments suffer from loss of appetite. By fixing that, lithium orotate can indirectly lead to weight gain– albeit often in situations where weight gain may be desirable.

Lithium is a trace element whose use in human health has been increasingly recognized. While its best-known role is that of supporting mood, lithium has recently been recognized as having the ability to play a role in maintaining cognitive function. 1,2 Hely M.A., Reid W.G., Adena M.A., Halliday G.M., Morris J.G. The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years. Mov. Disord. 2008; 23:837–844. [ PubMed] [ Google Scholar] Lithium orotate, carbonate and chloride: pharmacokinetics, polyuria in rats.” British Journal of Pharmacology (1976) Lithium in the prophylaxis of unipolar depression: a review” Journal of the Royal Society of Medicine (1983)Volakakis N., Kadkhodaei B., Joodmardi E., Wallis K., Panman L., Silvaggi J., Spiegelman B.M., Perlmann T. NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection. Proc. Natl. Acad. Sci. USA. 2010; 107:12317–12322. [ PMC free article] [ PubMed] [ Google Scholar]

Youdim M.B., Arraf Z. Prevention of MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) dopaminergic neurotoxicity in mice by chronic lithium: involvements of Bcl-2 and Bax. Neuropharmacology. 2004; 46:1130–1140. [ PubMed] [ Google Scholar] Lawson R.A., Yarnall A.J., Duncan G.W., Breen D.P., Khoo T.K., Williams-Gray C.H., Barker R.A., Collerton D., Taylor J.P., Burn D.J., group I-Ps Cognitive decline and quality of life in incident Parkinson's disease: the role of attention. Park. Relat. Disord. 2016; 27:47–53. [ PMC free article] [ PubMed] [ Google Scholar] Inhibiting the GSK3 enzyme may also help maintain healthy glucose levels already within normal range. 5,6 Guttuso T., Jr., Sirica D., Tosun D., Zivadinov R., Pasternak O., Weintraub D., Baglio F., Bergsland N. Thalamic dorsomedial nucleus free water correlates with cognitive decline in Parkinson's disease. Mov. Disord. 2022; 37:490–501. [ PMC free article] [ PubMed] [ Google Scholar] of our customers recommend us to family and friends. We're very proud of that because our loved ones matter to us—and we're willing to bet you feel the same way. Product Transparency

Does lithium orotate work?

PD: Parkinson’s disease, PBMC: peripheral blood mononuclear cell, Nurr1: nuclear receptor-related 1 protein, SOD1: superoxide dismutase 1, BDNF: brain-derived neurotrophic factor, GSK3β: glycogen synthase kinase-3 beta.

Poniedziałek B, Niedzielski P, Kozak L, Rzymski P, Wachelka M, Rzymska I, Karczewski J, Rzymski P (2018) Monitoring of essential and toxic elements in multi-ingredient food supplements produced in European Union. J Consum Prot Food Saf 13:41–48 Some case reports state confusion as one of the possible side effects, but it may result from other conditions. One study examining the effects of long-term low-dose lithium treatment found that it doesn’t impair kidney function. However, several other side effects were observed, such as a higher incidence of diabetes mellitus, increased body weight, increased neutrophils and thyroid-stimulating hormone (TSH), and occurrence of arrhythmias. Because several studies have shown pSN FW to be a disease-progression biomarker in PD ( Ofori et al., 2015, Burciu et al., 2017), the monoamine oxidase B (MAO-B) inhibitor rasagiline, which has several neuroprotective actions, was recently studied in a randomized controlled trial in PD to assess its effects on this outcome ( Arpin et al., 2021). The results showed rasagiline to not significantly affect longitudinal pSN FW progression; however, the placebo group did have over a 4-fold higher 1-year increase in pSN FW compared to the rasagiline group. Our findings of longitudinal reductions in pSN FW associated with medium-dose lithium aspartate therapy for 24 weeks contrasts the findings from this study with rasagiline. Although rasagiline has several neuroprotective mechanisms of action, it has never been shown to affect Nurr1 expression. Lithium, on the other hand, does not inhibit MAO-A or MAO-B and robustly increases Nurr1 expression in PC12 cells ( Nag, 2004; Zhang et al., 2016). Lithium also has anti-inflammatory and autophagy-enhancing actions that have not been described for rasagiline. Rybakowski JK, Lehmann W (1994) Decreased activity of erythrocyte membrane ATPases in depression and schizophrenia. Neuropsychobiol 30(1):11–14

What is lithium orotate?

Lithium has been discovered to inhibit the GSK3 enzyme. This enzyme plays a role in the amyloid cascade whereby amyloid beta accumulation in the brains of Alzheimer’s disease patients causes hyperphosphorylation of tau protein, which results in the formation of tangles that contribute to cognitive decline. 2,3 Lithium also supports autophagy, a metabolic process that can help break down harmful tau and amyloid beta proteins. 2 In rodent studies, lithium helped maintain memory and cognitive performance. 4 You can ask your doctor for a referral to a psychologist or other mental health professional who uses Ofori E., Pasternak O., Planetta P.J., Li H., Burciu R.G., Snyder A.F., Lai S., Okun M.S., Vaillancourt D.E. Longitudinal changes in free-water within the substantia nigra of Parkinson's disease. Brain. 2015; 138:2322–2331. [ PMC free article] [ PubMed] [ Google Scholar] Kjølholt J, Stuer-Lauridsen F, Skibsted Morgensen A, Havelund S (2003) The elements in the second rankan environmental problem now or in the future? Environmental Project No. 770. Miljøprojekt. Danish EPA. Danish Ministry of the Environment