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One patient with metastasized prostate cancer had 50% fewer prostate-specific antigen (PSA) in his system after 16 weeks on modified citrus pectin. And other “modified” pectins may simply indicate that the pectin has been altered in some way, but doesn’t contain the shorter polysaccharide chains and molecular structure required for efficacy.
Since PectaSol is a dietary fiber, some individuals may experience loose stools at the start of use. A rice-based diet with pectin (4 g/kg for 1 week) reduced vomiting in a clinical trial on 62 boys with diarrhea [ 11]. Safe heavy metal chelation: Three clinical studies highlight MCP as a safe chelator of heavy metals. In addition, hydrogen peroxide (H 2O 2)-induced damage was significantly reduced in HT29 cells, and CaCo-2 cell barrier function was increased, a process associated with reduced tumor promotion and metastatic potential [ 27].
In the production of PectaSol, the ratio of sodium to potassium is carefully controlled to resemble the ratio naturally present. MCP is shown to bind to toxic metals in the circulation, reducing blood levels and increasing the urinary excretion of lead, mercury, arsenic, cadmium and others — without disrupting essential minerals. In 2 clinical trials on over 100 children with persistent diarrhea, 4 g/kg pectin effectively improved this condition.
As a dietary supplement, for maximum support, take one 5 gram scoop 3 times daily with liquid on an empty stomach, or as recommended by your health care practitioner. For cases of sepsis, which involves toxicity from pathogenic microorganisms in the blood organs, or other tissues, MCP may lower death rates. But the modified version has shorter carbohydrate chains and a lower molecular weight [ 1], allowing it to be absorbed into the bloodstream where it can then potentially exert benefits. Several studies using preclinical models have demonstrated that “Gal-3 gene knockout” mice — tha is, those without the genetic ability to produce Gal-3 — are healthier overall than Gal-3 producing mice, as measured by markers of inflammation, fibrotic response and others. In another trial on 96 overweight women, pectin only caused a slight, non-significant reduction in calorie intake [ 44, 45, 46].Circulating Gal-3 is often substantially elevated in patients with cancer, particularly metastatic cancer. The lower incidence of liver metastases and smaller tumor volumes with high MCP concentrations show that it may inhibit colon cancer growth and metastasis in a dose-dependent manner. The original and only proven effective form of MCP is prepared with a proprietary, non-GMO enzymatic process controlled by pH and heat, which breaks the long chain molecules of the native pectin to produce the correct molecular size and structure of <13 kilodaltons and <5% esterification.
Galectins are an evolutionarily ancient family of proteins that share a high binding affinity for carbohydrates with β-galactoside linkages. Consult your healthcare professional prior to use if you have or suspect a medical condition, are taking any medications, or are nursing, pregnant or considering pregnancy. MCP may help to suppress cancer cells from grouping together, forming adhesions, or developing a metastasis by acting as a ligand — a substance that binds to another chemical to form something larger. Urinary bladder cancer (UBC) was the sixth-most frequent malignancy among males worldwide in 2012 [ 41].
If you want to use it as a supportive measure, talk to your doctor to avoid any unexpected interactions. Due to its gel-like consistency, pectin is a popular addition to foods as a thickening agent and a great source of fiber with many potential health benefits [ 4]. The cytotoxic effects of pectin-capped gold nanoparticles (PEC-AuNPs) and doxorubicin (DOX) and their combination (DOX-PEC-AuNPs) on HepG2 and HeLa cells have been compared. After six months, 78% ( n = 46) responded to therapy, with a decreased/stable PSA in 58% ( n = 34), or improvement of PSADT in 75% ( n = 44), and with negative scans, and entered the second twelve months treatment phase. Similarly, the expression of Gal-3, a lectin implicated in cell adhesion, cell cycle, and death, was reduced by CP and AP.
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